Med. Pro Praxi 2009; 6(1): 17-21

ADVANCE Study - glucose control arm: importance of intensive hyperglycaemia intervention for development of vascular diabetic complications

MUDr.. Marcela Szabó
Interní klinika - Diabetologické centrum, 2. LF UK a FN, Praha Motol

The ADVANCE Study assesses the clinical impact of intensive treatment for blood pressure and hyperglycaemia in type 2 diabetics on the

occurrence of macrovascular and microvascular diabetic complications. The results of the blood pressure-lowering arm and their importance

for diabetic complications were reported in numerous journals last year. The glucose control arm proved a statistically significant

decrease in microvascular complications (nephropathy, in particular) and a statistically insignificant decrease in macrovascular episodes

in the intensive treatment group compared to the standard treatment group.

Keywords: intensive glycaemic compensation, macrovascular and microvascular diabetic complications, modified-release gliclazide.

Published: March 1, 2009  Show citation

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Szabó M. ADVANCE Study - glucose control arm: importance of intensive hyperglycaemia intervention for development of vascular diabetic complications. Med. praxi. 2009;6(1):17-21.
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    References

    1. Patel A. ADVANCE Collaborative Group, MacMahon S, Chalmers J, Neal B, et al. Effects of fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the Advance trial): a randomised controlled trial. Lancet 2007; 370; 804-805. Go to original source... Go to PubMed...
    2. The ADVANCE Collaborative Group: Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes. N Eng J Med 2008; 358: 2560-2572. Go to original source... Go to PubMed...
    3. www.advance-trial.com.
    4. www.accordtrial.org.
    5. Dluhy RG, McMohon GT. Intensive Glycemic Control in the ACCORD and ADVANCE Trials. N Eng J Med 2008; 358: 2630-2633. Go to original source... Go to PubMed...
    6. The ACCORD study Group. Effects of Intensive Glucose Lowering in type 2 Diabetes. N Engl J Med 2008; 358: 2545-2559. Go to original source... Go to PubMed...

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