Med. praxi. 2011;8(1):10-15

The use of probiotics, prebiotics and synbiotics

prof.Ing.Vojtěch Rada, CSc.
Katedra mikrobiologie, výživy a dietetiky,
Fakulta agrobiologie potravinových a přírodních zdrojů, Česká zemědělská univerzita v Praze

Probiotics are defined as “live microorganisms, which when administered in adequate amounts confer a health benefit on the host”.

Probiotics strains are usually bacterial species normally commensal in the human intestinal tract. Genera Lactobacillus and Bifidobacterium

are most frequently used probiotic bacteria. Beneficial effects of probiotics on human health include alleviation of allergies, immunomodulation,

prevention of colon carcinoma, alleviation of constipation and the prevention and supportive therapy of inflammatory

bowel diseases and diarrhoea. Prebiotics are non-digestible carbohydrate foods or food ingredients that selectively stimulate the growth

and/or activity of one or more of limited number of bacteria in the colon that have the potential to improve health. Inulin, oligofructose,

galactooligosaccharides and lactulose fulfil all the criteria for prebiotic classification. The current most popular target for prebiotic use

are bifidobacteria. Synbiotics are a combination of probiotics and prebiotics. The example of synbiotic food is fermented milk products

(yoghurt) containing bifidobacteria and supplemented with oligofructose.

Keywords: probiotics, prebiotics, synbiotics, lactobacilli, bifidobacteria

Published: January 28, 2011  Show citation

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Rada V. The use of probiotics, prebiotics and synbiotics. Med. praxi. 2011;8(1):10-15.
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References

  1. Lilly DM, Sillwell RH. Probiotics: growth promoting factors produced by microorganisms. Science 1965; 147: 747-748. Go to original source... Go to PubMed...
  2. Fuller R. Probiotics in man and animals. J Appl Bacteriol 1989; 66: 365-378. Go to original source... Go to PubMed...
  3. FAO/WHO Joint Expert Consultation on Evaluation of Health and Nutritional Properties of Probiotics in Food Including Powder Milk with Live Lactic Acid Bacteria, October 2001.
  4. Walker a Buckley, 2006.
  5. FAO/WHO Report of Joint Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food, London Ontario, Canada, April 30 and May 1, 2002.
  6. Thomas LV, Marks J. An Introduction to the potential of probiotics in primary healthcare. Yakult UK Ltd., 2008: 57 s.
  7. Lodinová-Žádníková R, Cukrowská B, Tlaskalová-Hogenová H. Oral administration of probiotic Escherichia coli after birth reduces frequency of allergies and repeated infections later in life (after 10 and 20 years). Int Arch Allergy Immunol 2003; 131(3): 209-211. Go to original source... Go to PubMed...
  8. Kukkonen K, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, Tuure T, Kuitunen M. Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, doubl-blind, placebo-controlled trial. Pediatrics 2008; 122(3): 8-12. Go to original source... Go to PubMed...
  9. Rafter J, Bennet M, Caderni G, Cline Y, Hughes R, Karlsson PC, Klinder A, O'Riordan M, O'Sullivan GC, Pool-Zobel B, Rechkemmer G, Roller M, Rowland I, Salvadori M, Thijs H, Van Loo J, Watzl B, Collins JK. Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients. Am J Clin Nutr 2007; 85: 488-496. Go to original source... Go to PubMed...
  10. Davis CD, Milner JA. Gastrointestinal microflora, food components and colon cancer prevention. J Nutr Biochem 2009; 20: 743-752. Go to original source... Go to PubMed...
  11. Banaszkiewicz A, Szajewska H. Probiotics in the treatment of constipation: a systematic review of randomized controlled trials. Pediatr Wspolczesna 2005; 7: 9-14.
  12. Hickson M, D'Souza A, Muthu N, Rogers TR, Want S, Rajkumar C, Bulpitt CJ. Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial. BMJ 2007; 335: 80-83. Go to original source... Go to PubMed...
  13. Bleichner G, Bléhaut H, Mentec H, Moyse D. Saccharomyces boulardii prevents diarrhoea in critically ill tube fed patients. Intensive Care Medicine 1997; 23: 517-523. Go to original source... Go to PubMed...
  14. Miller K, Fraser T. What is the role of probiotics in the treatment of acute Clostridium difficile-associated diarrhea? Cleveland clinic Journal of Medicine 2009; 76: 391-392. Go to original source... Go to PubMed...
  15. Urbancsek H, Kazar T, Mezes I, Neumann K. Results of double-blind, randomized study to evaluate the efficacy and safety of Antibiophilus in patients with radiation-induced diarrhea. Eur J Gastroenterol Hepatol 2001; 13: 391-396. Go to original source... Go to PubMed...
  16. Canani RB, Cirillo P, Terrin G, Cesarano L, Spagnuolo MI. Probiotics for treatment of acute diarrhoea in children: randomised clinical trial of five different preparations. BMJ 2007; 335: 340. Go to original source... Go to PubMed...
  17. Oksanen PJ, Salminen S, Saxelin M. Prevention of travellers' diarhoea by Lactobacillus GG. Annals of Medicine 1990; 22: 53-56. Go to original source... Go to PubMed...
  18. Tubelius P, Stan V, Zachrisson A. Increasing work-place healthiness with the probiotic Lactobacillus reuteri: a randomised, double-blind placebo controlled study. Environ Health 2005; 4: 25. Go to original source... Go to PubMed...
  19. Gionchetti, a kol., 2007.
  20. MacConnachie, a kol., 2009.
  21. Besselink MG, Santvoort HC, Buskens E, Boermeester MA, van GOOR H, Timmerman HM, Nieuwenhuijs VB, Bollen TL, van Ramshorst B, Witteman BJ, Rosman C, Ploeg RJ, Brink MA, Schaaphender AF, Dejong CH, Wahab PJ, van Laarhoven CJ, van der Harst E, van Eijck CH, Cuesta MA, Akkermans LM, Gooszen HG. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet 2008; 371: 1246. Go to original source... Go to PubMed...
  22. Gibson G, Roberfroid MB. Dietary modulation of the colonic microbiota: introducing the concept of prebiotics. J Nutr 1995; 125: 1401-1412. Go to original source... Go to PubMed...
  23. Roberfroid M. Prebiotics: the concept revisited. J Nutr 2007; 137: 830S-837S. Go to original source... Go to PubMed...
  24. Depeint F, Tzortzis G, Vulevic J, I´Anson K, Gibson GR. Prebiotic evaluation of a novel galactooligosaccharide mixture produced by the enzymatic activity of Bifidobacterium bifidum NCIMB 41171, in healthy humans: a randomized, double-blind, crossover, placebo-controlled intervention study. Am J Clin Nutr 2008; 87: 785-791. Go to original source... Go to PubMed...
  25. Beighton D. Can the ecology of the dental biofilm be beneficially altered? Adv Dent Res 2009; 21: 69-73. Go to original source... Go to PubMed...




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