Med. praxi. 2012;9(5):233-237
Thyroid disease in pregnancy
- 3. Interní klinika 1. LF UK a VFN Praha
Thyroid disease affects a significant proportion of women of childbearing age and, when untreated, it may cause infertility, complications
in pregnancy, and fetal developmental defects. Laboratory standards for thyroid parameters are different from those for the general
population. The most reliable and best standardized parameter in pregnancy is serum thyroid-stimulating hormone (TSH) which should
be kept in the range of 0.1–2.5 mIU/L in the first trimester. Hypothyroidism in pregnancy must always be treated, with replacement
therapy being initiated with a full dose and the TSH level maintained up to 2.5 mIU/L. Propylthiouracyl is used to treat hyperthyroidism
in pregnancy in the first trimester and methimazole is used since the second trimester and during breastfeeding. There is not sufficient
evidence for systemic treatment of autoimmune thyroid disease without thyroid dysfunction in pregnancy and an individual approach
is taken. In all pregnant women at risk or those planning to become pregnant, screening for TSH and anti-thyroid peroxidase antibodies
should be done in early pregnancy or before conception.
peroxidase antibodies.
Keywords: hypothyroidism, subclinical hypothyroidism, hyperthyroidism, pregnancy, thyroid-stimulating hormone, anti-thyroid
Published: May 31, 2012 Show citation
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