Med. praxi. 2019;16(2):118-120

Omega-3 fatty acids essential to the central nervous system

MUDr. Jiří Slíva, Ph.D.
Ústav farmakologie 3. LF UK, Praha

Omega-3 polyunsaturated fatty acids (FA) are highly valued for their beneficial effects on human health. The article focuses on
mapping their benefits from the point of view of psychiatric illnesses (namely depression), however, they are intensively studied
practically across all branches of medicine.

Keywords: polyunsaturated fatty acids, PUFA, omega-3, docosahexaenoic acid, DHA, eicosapentaenoic acid, EPA, mood disorders, depression

Published: April 15, 2019  Show citation

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Slíva J. Omega-3 fatty acids essential to the central nervous system. Med. praxi. 2019;16(2):118-120.
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References

  1. Das UN. Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules. Lipids Health Dis 2008; 7: 37. Go to original source... Go to PubMed...
  2. Das UN. Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer's disease-but how and why? Prostaglandins Leukot Essent Fatty Acids 2008; 78: 11-19. Go to original source... Go to PubMed...
  3. Bazan NG. Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection. Prostaglandins Leukot Essent Fatty Acids 2009; 81: 205-211. Go to original source... Go to PubMed...
  4. He C, Qu X, Cui L, et al. Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid. Proc Natl Acad Sci U S A 2009; 106: 11370-11375. Go to original source... Go to PubMed...
  5. Conklin SM, Gianaros PJ, Brown SM, et al. Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults. Neurosci Lett 2007; 421: 209-212. Go to original source... Go to PubMed...
  6. Haag M. Essential fatty acids and the brain. Can J Psychiatry 2003; 48: 195-203. Go to original source... Go to PubMed...
  7. Su KP. Biological mechanism of antidepressant effect of omega-3 fatty acids: how does fish oil act as a 'mind-body interface'? Neurosignals 2009; 17: 144-152. Go to original source... Go to PubMed...
  8. Kang JX, Gleason ED. Omega-3 Fatty acids and hippocampal neurogenesis in depression. CNS Neurol Disord Drug Targets 2013; 12: 460-465. Go to original source... Go to PubMed...
  9. Rapoport SI, Bosetti F. Do lithium and anticonvulsants target the brain arachidonic acid cascade in bipolar disorder? Arch Gen Psychiatry 2002; 59: 592-596. Go to original source... Go to PubMed...
  10. Wani AL, Bhat SA, Ara A. Omega-3 fatty acids and the treatment of depression: a review of scientific evidence. Integr Med Res 2015; 4: 132-141. Go to original source... Go to PubMed...
  11. Hibbeln JR. Depression, suicide and deficiencies of omega-3 essential fatty acids in modern diets. World Rev Nutr Diet 2009; 99: 17-30. Go to original source... Go to PubMed...
  12. Adams PB, Lawson S, Sanigorski A, et al. Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression. Lipids 1996; 31(Suppl): S157-S161. Go to original source... Go to PubMed...
  13. Tiemeier H, van Tuijl HR, Hofman A, et al. Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study. Am J Clin Nutr 2003; 78: 40-46. Go to original source... Go to PubMed...
  14. Edwards R, Peet M, Shay J, et al. Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. J Affect Disord 1998; 48: 149-155. Go to original source... Go to PubMed...
  15. Peet M, Murphy B, Shay J, et al. Depletion of omega-3 fatty acid levels in red blood cell membranes of depressive patients. Biol Psychiatry 1998; 43: 315-319. Go to original source... Go to PubMed...
  16. Maes M, Smith R, Christophe A, et al. Fatty acid composition in major depression: decreased omega 3 fractions in cholesteryl esters and increased C20: 4 omega 6/C20:5 omega 3 ratio in cholesteryl esters and phospholipids. J Affect Disord 1996; 38: 35-46. Go to original source... Go to PubMed...
  17. McNamara RK, Jandacek R, Rider T, et al. Effects of fish oil supplementation on prefrontal metabolite concentrations in adolescents with major depressive disorder: a preliminary 1H MRS study. Nutr Neurosci 2016; 19: 145-155. Go to original source... Go to PubMed...
  18. Krawczyk K, Rybakowski J. Augmentation of antidepressants with unsaturated fatty acids omega-3 in drug-resistant depression. Psychiatr Pol 2012; 46: 585-598. Go to PubMed...
  19. Mozaffari-Khosravi H, Yassini-Ardakani M, Karamati M, et al. Eicosapentaenoic acid versus docosahexaenoic acid in mild-to-moderate depression: a randomized, double-blind, placebo-controlled trial. Eur Neuropsychopharmacol 2013; 23: 636-644. Go to original source... Go to PubMed...
  20. Sublette ME, Ellis SP, Geant AL, et al. Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression. J Clin Psychiatry 2011; 72: 1577-1584. Go to original source... Go to PubMed...
  21. Safa M, Fallah TS, Ghassem BF, et al. Clinical trial in the treatment of 80 Iranian patients with major depression disorder by the combination of omega 3 fatty acid and a selective serotonin reuptake inhibitor. Ther Adv Psychopharmacol 2013; 3: 186-190. Go to original source... Go to PubMed...
  22. Lin PY, Su KP. A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids. J Clin Psychiatry 2007; 68: 1056-1061. Go to original source... Go to PubMed...
  23. Grosso G, Pajak A, Marventano S, et al. Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials. PLoS One 2014; 9: e96905. Go to original source... Go to PubMed...
  24. Sarris J, Murphy J, Mischoulon D, et al. Adjunctive nutraceuticals for depression: a systematic review and meta-analyses. Am J Psychiatry 2016; 173: 575-587. Go to original source... Go to PubMed...
  25. Schefft C, Kilarski LL, Bschor T, et al. Efficacy of adding nutritional supplements in unipolar depression: a systematic review and meta-analysis. Eur Neuropsychopharmacol 2017; 27: 1090-1109. Go to original source... Go to PubMed...
  26. Rice SM, Hickie IB, Yung AR, et al. Youth depression alleviation: the Fish Oil Youth Depression Study (YoDA-F): A randomized, double-blind, placebo-controlled treatment trial. Early Interv Psychiatry 2016; 10: 290-299. Go to original source... Go to PubMed...
  27. Sanchez-Villegas A, Alvarez-Perez J, Toledo E, et al. Seafood consumption, omega-3 fatty acids intake, and life-time prevalence of depression in the PREDIMED-Plus trial. Nutrients 2018; 10. Go to original source... Go to PubMed...
  28. Deprese. Doporučené diagnostické a terapeutické postupy pro všeobecné praktické lékaře 2018. Novelizace 2018 [online]. Dostupné z: www.svl.cz/files/files/Doporucene-postupy/2017/DP-Deprese.pdf
  29. American Psychiatric Association Practice Guidelines for Major Depressive Disorder. (November 2010)
  30. Cleare A, Pariante CM, Young AH, et al. Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines. J Psychopharmacol 2015; 29: 459-525. Go to original source... Go to PubMed...
  31. Ravindran AV, Balneaves LG, Faulkner G, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical guidelines for the management of adults with major depressive disorder: Section 5. Complementary and alternative medicine treatments. Can J Psychiatry 2016; 61: 576-587. Go to original source... Go to PubMed...
  32. Maes M, Yirmyia R, Noraberg J, et al. The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads future research and new drug developments in depression. Metab Brain Dis 2009; 24: 27-53. Go to original source... Go to PubMed...
  33. Hibbeln JR. Fish consumption and major depression. Lancet 1998; 351: 1213. Go to original source... Go to PubMed...




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