Med. praxi. 2021;18(2):92-96 | DOI: 10.36290/med.2021.015

Anaphylaxis

MUDr. Magdalena Herknerová, Ph.D.
Anacarde, s. r. o., ordinace alergologie a klinické imunologie, Mníšek pod Brdy

Anaphylaxis is a serious systemic hypersensitivity reaction. Anaphylaxis is caused by the systemic release of mediators (histamine, tryptase et al.) from the effector cells (mastocytes et al.). Anaphylactic reaction affects more systems and is potentially fatal. The most frequent triggers are food, drugs, insect venoms. The etymology of the word "anaphylaxis" is explained. The paper presents the current knowledge of pathophysiology, phenotypes, triggers, risk factors and cofactors. The most important part focuses on the epinephrine autoinjektor as the life-saving emergency medication without absolute contraindication.

Keywords: anaphylaxis, epinephrine, auto-injector, mastocytes, allergy, tryptase.

Published: April 30, 2021  Show citation

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Herknerová M. Anaphylaxis. Med. praxi. 2021;18(2):92-96. doi: 10.36290/med.2021.015.
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