Med. praxi. 2024;21(1):18-25 | DOI: 10.36290/med.2024.002

Histamine intolerance

MUDr. Martin Fuchs
Immuno-flow, s. r. o., Praha

Histamine intolerance (HI, HIT) may also be referred to as enteral histaminosis or hypersensitivity to oral/food histamine. It is the inability to degrade exogenous histamine due to impaired diaminooxidase (DAO) activity, resulting in symptoms of histamine excess. HI should be understood as a variable set of symptoms, neither a nosological entity nor a syndrome. The diagnosis of this metabolic disorder is made solely on the basis of clinical criteria and the demonstrated effect of a low histamine diet. No biomarkers are available for HI specificity. Both functional and absolute DAO deficiency can be caused by genetic, pharmacological or a broad heterogeneous group of primary enteropathies (secondary HI).

Keywords: histamine, histamine intolerance, DAO, diamine oxidase, low-histamine diet, food intolerance.

Received: January 3, 2024; Revised: January 25, 2024; Accepted: January 25, 2024; Published: March 6, 2024  Show citation

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Fuchs M. Histamine intolerance. Med. praxi. 2024;21(1):18-25. doi: 10.36290/med.2024.002.
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