Med. praxi. 2025;22(1):20-25 | DOI: 10.36290/med.2025.005

Acquired syphilis in adults

MUDr. Filip Skokan
I. dermatovenerologická klinika, LF MU Brno

Syphilis is a systemic, chronic, and worldwide spread infectious disease caused by the bacterium Treponema pallidum, and its only natural host is man. The disease is transmitted predominantly through sexual contact (90%), but transplacental infection and blood transmission are also possible; other routes of infection are rare. The severity of syphilis is determined by the risk of various organs, particularly the skin, eye, CNS, cardiovascular and musculoskeletal systems and the risk of transmission to the foetus during pregnancy or birth in an untreated mother. The article aims to provide comprehensive and concise information on acquired syphilis (lat. syphilis acquisita) in adults.

Keywords: syphilis, Treponema pallidum, syphilis diagnosis, syphilis disease therapy.

Received: December 6, 2024; Revised: January 16, 2025; Accepted: January 21, 2025; Published: February 20, 2025  Show citation

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Skokan F. Acquired syphilis in adults. Med. praxi. 2025;22(1):20-25. doi: 10.36290/med.2025.005.
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    References

    1. Kuklová I. Syfilis včera a dnes. Dermatol. praxi. 2012;6(3):136-7.
    2. Bolognia JL, Schaffer JV, Cerroni L. Dermatology. 2nd ed. Vol. 2. Elsevier; 2024. p. 1461-1473. ISBN: 9780702082252.
    3. Šmajs D, Strouhal M, Knauf S. Genetics of human and animal uncultivable treponemal pathogens. Infect Genet Evol. 2018 Jul;61:92-107. doi:10.1016/j.meegid.2018. 03. 015. Epub 2018 Mar 22. PMID: 29578082. Go to original source...
    4. Tampa M, Sarbu I, Matei C, et al. Brief history of syphilis. J Med Life. 2014;7(1):4-10. PMCID: PMC3956094.
    5. National Center for Biotechnology Information. Treponema pallidum (ID: 157) [Internet]. [cited 2024 Oct 14]. Available from: https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=157.
    6. Státní zdravotní ústav. Venerická syfilis (syphilis, lues venerea), česky příjice [Internet]. [cited 2024 Oct 14]. Available from: https://szu.cz/temata­‑zdravi­‑a­‑bezpecnosti/a­‑z­‑infekce/s/syfilis­‑prijice­‑lues/venericka­‑syfilis­‑syphilis­‑lues­‑venerea­‑cesky­‑prijice/.
    7. Centers for Disease Control and Prevention. Sexually transmitted disease surveillance 2022 [Internet]. 2023 [cited 2024 Oct 14]. Available from: https://www.cdc.gov/std/statistics/2022/default.htm.
    8. European Centre for Disease Prevention and Control. Syphilis: Annual epidemiological report for 2022. Stockholm: ECDC; 2024. p. 1.
    9. Rob F, Zákoucká H, Kružicová Z, et al. Doporučený postup pro diagnostiku a léčbu syfilidy v České republice. Česká dermatovenerologie. 2015;5(2):76-87.
    10. Janier M, Unemo M, Dupin N, et al. 2020 European guideline on the management of syphilis. J Eur Acad Dermatol Venereol. 2020;34(12):2675-2691.
    11. Ghanem KG, Ram S, Rice PA. The Modern Epidemic of Syphilis. N Engl J Med. 2020 Feb 27;382(9):845-854. doi: 10.1056/NEJMra1901593. PMID: 32101666. Go to original source... Go to PubMed...
    12. Magnuson HJ, Thomas EW, Olansky S, et al. Inoculation syphilis in human volunteers. Medicine (Baltimore). 1956 Feb;35(1):33-82. doi:10.1097/00005792-195602000-00002. PMID:13296652. Go to original source... Go to PubMed...
    13. Zákoucká H. Syfilis - tradiční choroba - současný problém II [Internet]. 2013 Sep 8 [cited 2024 Oct 14]. Available from: http://www.szu.cz/tema/prevence/syfilis­‑tradicni­‑choroba­‑soucasny­‑problem­‑ii.
    14. Branská L. Diagnostika syfilis [thesis]. Hradec Králové: Univerzita Karlova, Farmaceutická fakulta; 2014. p. 14-31.
    15. Resl V, et al. Základy depistáže a organizace venerologické práce. Plzeň: Západočeská univerzita a Státní zdravotní ústav; 2019. p. 72-80.
    16. World Health Organization. Syphilis [Internet]. Available from: https://www.who.int/news­‑room/fact­‑sheets/detail/syphilis. Accessed 2024 Nov 6.
    17. Rob F, Zákoucká H, Kružicová Z, et al. Doporučený postup pro diagnostiku a léčbu syfilidy v České republice. Česká dermatovenerologie. 2015;5(2):76-87.

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