Med. praxi. 2025;22(1):59-64 | DOI: 10.36290/med.2024.055

Prevention of cardiovascular diseases by reducing blood pressure variability with a fixed combination of antihypertensive drugs, case studies

MUDr. Ivan Řiháček, Ph.D.
Ordinace Řiháčkovi, s. r. o., Brno

Hypertension is the most important risk factor for cardiovascular diseases. Increased blood pressure variability worsens cardiovascular risk. Long-acting calcium channel blockers and thiazide or thiazide-like diuretics reduce blood pressure variability. Target blood pressure values in the new recommendations are 120-129/70-79 mmHg. To achieve them, we use in the first step a fixed combination of long-acting calcium channel blockers or diuretics with renin-angiotensin blockers. In the second step a fixed triple combination of all three drugs.

Keywords: hypertension, blood pressure variability, blood pressure targets, cardiovascular disease, fixed combination of antihypertensive drugs.

Received: December 12, 2024; Accepted: December 20, 2024; Published: February 20, 2025  Show citation

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Řiháček I. Prevention of cardiovascular diseases by reducing blood pressure variability with a fixed combination of antihypertensive drugs, case studies. Med. praxi. 2025;22(1):59-64. doi: 10.36290/med.2024.055.
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