Med. praxi. 2025;22(2):105-110 | DOI: 10.36290/med.2025.014

Fecal microbiota transplantation - current trends and future perspectives

MUDr. Roman Stebel, Ph.D.

Lékařská fakulta Masarykovy univerzity, Brno

Klinika infekčních chorob, Fakultní nemocnice Brno

Disruption of the human microbial ecosystem represents a significant pathogenic factor of many diseases. The role of altered intestinal microbiota in the pathogenesis of recurrent Clostridium difficile colitis has been known for decades. Still, severe disruptions in the composition or function of the microbiota (we are speaking about dysbiosis) is nowadays also described in the pathogenesis of other pathological conditions. In this sense, the most commonly listed are idiopathic inflammatory bowel diseases, irritable bowel syndrome, type 2 diabetes mellitus, multiple sclerosis, Parkinson's disease, furthermore, for example, hepatic encephalopathy in patients with liver cirrhosis. We try to therapeutically intervene on the level of damaged intestinal microbiota in various ways. One very promising method seeks to restore natural microbial homeostasis in the colon using stool from a healthy donor, which is transferred into the digestive tract of the patient. For us, this method became commonly known as "fecal bacteriotherapy". The international literature typically uses the term "Fecal Microbiota Transplantation" or by the abbreviation FMT.

Keywords: dysbiosis, Clostridioides difficile infection, microbiota, fecal microbiota transplantation.

Received: November 19, 2024; Revised: February 18, 2025; Accepted: February 24, 2025; Published: April 30, 2025  Show citation