Med. praxi. 2020;17(5):304-308 [Interní Med. 2019; 21(5): 270-274]

Probiotics use in geriatric medicine

MUDr. Jana Řádková
Interní gastroenterologická klinika FN Brno a LF MU Brno

The intestinal microbial composition changes with aging in a variable manner. The composition and function of gut microbiota closely correlates with health status of older adults. Microbiota-targeted interventions present a promising option for impacting longevity and healthy aging. Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host (1). The data obtained from younger age groups cannot be automatically extrapolated to the elderly, nor will results acquired from older individuals with a good health status necessarily apply to those with multiple co-morbidities or frailty. Therefore, additional clinical studies are needed to establish appropriate recommendations.

Keywords: probiotics, intestinal microbiota, elderly, aging, geriatric frailty.

Published: January 5, 2021  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Řádková J. Probiotics use in geriatric medicine. Med. praxi. 2020;17(5):304-308.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014; 11(8): 506-514. Go to original source... Go to PubMed...
    2. Bian G, Gloor GB, Gong A, Jia C, Zhang W, Hu J, et al. The Gut Microbiota of Healthy Aged Chinese Is Similar to That of the Healthy Young. mSphere. 2017; 2(5). Go to original source... Go to PubMed...
    3. Biagi E, Rampelli S, Turroni S, Quercia S, Candela M, Brigidi P. The gut microbiota of centenarians: Signatures of longevity in the gut microbiota profile. Mech Ageing Dev. 2017; 165(Pt B): 180-184. Go to original source... Go to PubMed...
    4. Wu L, Zeng T, Zinellu A, Rubino S, Kelvin DJ, Carru C. A Cross‑Sectional Study of Compositional and Functional Profiles of Gut Microbiota in Sardinian Centenarians. mSystems. 2019; 4(4). Go to original source... Go to PubMed...
    5. Blumberg R, Cho J, Lewis J, Wu G. Inflammatory bowel disease: an update on the fundamental biology and clinical management. Gastroenterology. 2011; 140(6): 1701-1703. Go to original source... Go to PubMed...
    6. Maffei VJ, Kim S, Blanchard E, Luo M, Jazwinski SM, Taylor CM, et al. Biological Aging and the Human Gut Microbiota. J Gerontol A Biol Sci Med Sci. 2017; 72(11): 1474-1482. Go to original source... Go to PubMed...
    7. Claesson MJ, Jeffery IB, Conde S, Power SE, O'Connor EM, Cusack S, et al. Gut microbiota composition correlates with diet and health in the elderly. Nature. 2012; 488(7410): 178-184. Go to original source... Go to PubMed...
    8. Vaiserman AM, Koliada AK, Marotta F. Gut microbiota: A player in aging and a target for anti‑aging intervention. Ageing Res Rev. 2017; 35: 36-45. Go to original source... Go to PubMed...
    9. Ouwehand AC. A review of dose‑responses of probiotics in human studies. Benef Microbes. 2017; 8(2): 143-151. Go to original source... Go to PubMed...
    10. Sanders ME, Merenstein D, Merrifield CA, Hutkins R. Probiotics for human use. Nutrition Bulletin. 2018; 43(3): 212-225. Go to original source...
    11. Quigley EMM. Prebiotics and Probiotics in Digestive Health. Clin Gastroenterol Hepatol. 2019; 17(2): 333-344. Go to original source... Go to PubMed...
    12. Duncan SH, Flint HJ. Probiotics and prebiotics and health in ageing populations. Maturitas. 2013; 75(1): 44-50. Go to original source... Go to PubMed...
    13. Sniffen JC, McFarland LV, Evans CT, Goldstein EJC. Choosing an appropriate probiotic product for your patient: An evidence‑based practical guide. PLoS One. 2018; 13(12): e0209205. Go to original source... Go to PubMed...
    14. McFarland LV, Evans CT, Goldstein EJC. Strain‑Specificity and Disease‑Specificity of Probiotic Efficacy: A Systematic Review and Meta‑Analysis. Front Med (Lausanne). 2018; 5: 124. Go to original source... Go to PubMed...
    15. Brüssow H. Probiotics and prebiotics in clinical tests: an update [version 1; peer review: 2 approved]. F1000Research. 2019; 8(1157). Go to original source... Go to PubMed...
    16. Rondanelli M, Faliva MA, Perna S, Giacosa A, Peroni G, Castellazzi AM. Using probiotics in clinical practice: Where are we now? A review of existing meta‑analyses. Gut Microbes. 2017; 8(6): 521-543. Go to original source... Go to PubMed...
    17. Cai J, Zhao C, Du Y, Zhang Y, Zhao M, Zhao Q. Comparative efficacy and tolerability of probiotics for antibiotic‑associated diarrhea: Systematic review with network meta‑analysis. United European gastroenterology journal. 2018; 6(2): 169-180. Go to original source... Go to PubMed...
    18. Shen NT, Maw A, Tmanova LL, Pino A, Ancy K, Crawford CV, et al. Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection: A Systematic Review With Meta‑Regression Analysis. Gastroenterology. 2017; 152(8): 1889-900.e9. Go to original source... Go to PubMed...
    19. He F, Ouwehand AC, Isolauri E, Hosoda M, Benno Y, Salminen S. Differences in composition and mucosal adhesion of bifidobacteria isolated from healthy adults and healthy seniors. Curr Microbiol. 2001; 43(5): 351-354. Go to original source... Go to PubMed...
    20. Yaqoob P. Ageing alters the impact of nutrition on immune function. Proc Nutr Soc. 2017; 76(3): 347-351. Go to original source... Go to PubMed...
    21. Setbo E, Campbell K, O'Cuiv P, Hubbard R. Utility of Probiotics for Maintenance or Improvement of Health Status in Older People - A Scoping Review. J Nutr Health Aging. 2019; 23(4): 364-372. Go to original source... Go to PubMed...
    22. Rondanelli M, Giacosa A, Faliva MA, Perna S, Allieri F, Castellazzi AM. Review on microbiota and effectiveness of probiotics use in older. World J Clin Cases. 2015; 3(2): 156-162. Go to original source... Go to PubMed...
    23. Gao R, Zhang X, Huang L, Shen R, Qin H. Gut Microbiota Alteration After Long‑Term Consumption of Probiotics in the Elderly. Probiotics Antimicrob Proteins. 2019; 11(2): 655-666. Go to original source... Go to PubMed...
    24. Eloe‑Fadrosh EA, Brady A, Crabtree J, Drabek EF, Ma B, Mahurkar A, et al. Functional dynamics of the gut microbiome in elderly people during probiotic consumption. MBio. 2015; 6(2). Go to original source... Go to PubMed...
    25. Qu H, Zhang Y, Chai H, Gao ZY, Shi DZ. Effects of microbiota‑driven therapy on inflammatory responses in elderly individuals: A systematic review and meta‑analysis. PLoS One. 2019; 14(2) :e0211233. Go to original source... Go to PubMed...
    26. Lefevre M, Racedo SM, Ripert G, Housez B, Cazaubiel M, Maudet C, et al. Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double‑blind placebo‑controlled study. Immun Ageing. 2015; 12: 24. Go to original source... Go to PubMed...
    27. Miller LE, Lehtoranta L, Lehtinen MJ. Short‑term probiotic supplementation enhances cellular immune function in healthy elderly: systematic review and meta‑analysis of controlled studies. Nutr Res. 2019; 64: 1-8. Go to original source... Go to PubMed...
    28. Hao Q, Dong BR, Wu T. Probiotics for preventing acute upper respiratory tract infections. Cochrane Database Syst Rev. 2015(2):CD006895. Go to original source...
    29. Guillemard E, Tondu F, Lacoin F, Schrezenmeir J. Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial. Br J Nutr. 2010; 103(1): 58-68. Go to original source... Go to PubMed...
    30. Shinkai S, Toba M, Saito T, Sato I, Tsubouchi M, Taira K, et al. Immunoprotective effects of oral intake of heat‑killed Lactobacillus pentosus strain b240 in elderly adults: a randomised, double‑blind, placebo‑controlled trial. Br J Nutr. 2013; 109(10): 1856-1865. Go to original source... Go to PubMed...
    31. Zimmermann P, Curtis N. The influence of probiotics on vaccine responses - A systematic review. Vaccine. 2018; 36(2): 207-213. Go to original source... Go to PubMed...
    32. Lei WT, Shih PC, Liu SJ, Lin CY, Yeh TL. Effect of Probiotics and Prebiotics on Immune Response to Influenza Vaccination in Adults: A Systematic Review and Meta‑Analysis of Randomized Controlled Trials. Nutrients. 2017; 9(11). Go to original source... Go to PubMed...
    33. Boge T, Rémigy M, Vaudaine S, Tanguy J, Bourdet‑Sicard R, van der Werf S. A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials. Vaccine. 2009; 27(41): 5677-5684. Go to original source... Go to PubMed...
    34. Fonollá J, Gracián C, Maldonado‑Lobón JA, Romero C, Bédmar A, Carrillo JC, et al. Effects of Lactobacillus coryniformis K8 CECT5711 on the immune response to influenza vaccination and the assessment of common respiratory symptoms in elderly subjects: a randomized controlled trial. Eur J Nutr. 2019; 58(1): 83-90. Go to original source... Go to PubMed...
    35. Bosch M, Méndez M, Pérez M, Farran A, Fuentes MC, Cuñé J. Lactobacillus plantarum CECT7315 and CECT7316 stimulate immunoglobulin production after influenza vaccination in elderly. Nutr Hosp. 2012; 27(2): 504-509. Go to PubMed...
    36. Ai R, Wei J, Ma D, Jiang L, Dan H, Zhou Y, et al. A meta‑analysis of randomized trials assessing the effects of probiotic preparations on oral candidiasis in the elderly. Arch Oral Biol. 2017; 83: 187-192. Go to original source... Go to PubMed...
    37. Xie C, Li J, Wang K, Li Q, Chen D. Probiotics for the prevention of antibiotic‑associated diarrhoea in older patients: a systematic review. Travel Med Infect, DiS. 2015; 13(2): 128-134. Go to original source... Go to PubMed...
    38. Goldenberg JZ, Yap C, Lytvyn L, Lo CK, Beardsley J, Mertz D, et al. Probiotics for the prevention of Clostridium difficile‑associated diarrhea in adults and children. Cochrane Database Syst Rev. 2017; 12: CD006095. Go to original source... Go to PubMed...
    39. Allen SJ, Wareham K, Wang D, Bradley C, Hutchings H, Harris W, et al. Lactobacilli and bifidobacteria in the prevention of antibiotic‑associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double‑blind, placebo‑controlled, multicentre trial. Lancet 2013; 382(9900): 1249-1257. Go to original source... Go to PubMed...
    40. Kuntz JL, Smith DH, Petrik AF, Yang X, Thorp ML, Barton T, et al. Predicting the Risk of Clostridium difficile Infection upon Admission: A Score to Identify Patients for Antimicrobial Stewardship Efforts. Perm J. 2016; 20(1): 20-25. Go to original source... Go to PubMed...
    41. Martínez‑Martínez MI, Calabuig‑Tolsá R, Cauli O. The effect of probiotics as a treatment for constipation in elderly people: A systematic review. Arch Gerontol Geriatr. 2017; 71: 142-149. Go to original source... Go to PubMed...
    42. Lei M, Hua LM, Wang DW. The effect of probiotic treatment on elderly patients with distal radius fracture: a prospective double‑blind, placebo‑controlled randomised clinical trial. Benef Microbes. 2016; 7(5): 631-637. Go to original source... Go to PubMed...
    43. Nilsson AG, Sundh D, Bäckhed F, Lorentzon M. Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo‑controlled, double‑blind, clinical trial. J Intern Med. 2018; 284(3): 307-317. Go to original source... Go to PubMed...
    44. Akbari E, Asemi Z, Daneshvar Kakhaki R, Bahmani F, Kouchaki E, Tamtaji OR, et al. Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double‑Blind and Controlled Trial. Front Aging Neurosci. 2016; 8: 256. Go to original source... Go to PubMed...
    45. Agahi A, Hamidi GA, Daneshvar R, Hamdieh M, Soheili M, Alinaghipour A, et al. Does Severity of Alzheimer's Disease Contribute to Its Responsiveness to Modifying Gut Microbiota? A Double Blind Clinical Trial. Front Neurol. 2018; 9: 662. Go to original source... Go to PubMed...
    46. Tamtaji OR, Taghizadeh M, Daneshvar Kakhaki R, Kouchaki E, Bahmani F, Borzabadi S, et al. Clinical and metabolic response to probiotic administration in people with Parkinson's disease: A randomized, double‑blind, placebo‑controlled trial. Clin Nutr. 2019; 38(3): 1031-1035. Go to original source... Go to PubMed...
    47. Valentini L, Pinto A, Bourdel‑Marchasson I, Ostan R, Brigidi P, Turroni S, et al. Impact of personalized diet and probiotic supplementation on inflammation, nutritional parameters and intestinal microbiota - The "RISTOMED project": Randomized controlled trial in healthy older people. Clin Nutr. 2015; 34(4): 593-602. Go to original source... Go to PubMed...
    48. Hata Y, Yamamoto M, Ohni M, Nakajima K, Nakamura Y, Takano T. A placebo‑controlled study of the effect of sour milk on blood pressure in hypertensive subjects. Am J Clin Nutr. 1996; 64(5): 767-771. Go to original source... Go to PubMed...
    49. Aoyagi Y, Park S, Matsubara S, Honda Y, Amamoto R, Kushiro A, et al. Habitual intake of fermented milk products containing Lactobacillus casei strain Shirota and a reduced risk of hypertension in older people. Benef Microbes. 2017; 8(1): 23-29. Go to original source... Go to PubMed...

    Return to the content


    Medicine for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.