Med. Pro Praxi 2007; 4: 165-168

Hirsutizmus

MUDr. Jana Heresová CSc1,2, MUDr. Marie Vrzáňová3
1 Endokrinologický ústav, Praha
2 Klinika nukleární medicíny UK 2. LF Praha a FN Motol
3 Interní klinika fakultní nemocnice Motol a 2. lékařské fakulty Univerzity Karlovy v Praze

Hirsutizmus je patologický růst a distribuce ochlupení u žen způsobená androgenní stimulací pilosebaceosní jednotky. Příčina je multifaktoriální a závisí na etnickém nebo familiárním výskytu, hormonální poruše s nadprodukcí androgenů ve steroidogenní žláze (nadledviny, ovaria), paraendokrinní sekreci nádoru, iatrogenní příčině, genových abnormalitách aj. Výskyt zvýšené tvorby ochlupení u žen je mezi 5–10 %. Autorky rozebírají nejčastější příčiny hirsutizmu a hypertrichózy u žen jako příznaku poruchy tvorby terminálního vlasu vlivem hormonální poruchy, enzymové distribuce, metabolických, nádorových a jiných stavů. Podávají přehled současných terapeutických postupů.

Keywords: hirsutizmus, hypertrichóza, androgeny, enzymy, léčba

Published: June 1, 2007  Show citation

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Heresová J, Vrzáňová M. Hirsutizmus. Med. praxi. 2007;4(4):165-168.
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References

  1. Azziz R, Carmina E, Sawaya ME. Idiopatic Hirsutism. Endocr. Rew. 2000; 21: 347-362. Go to original source...
  2. Bayram F, Muderris I, Guven M et al. Low-dose (2, 5 mg/day) finasteride treatment in hirsutism. Gynecol. Endocrinol. 2003;17(5): 419-422. Go to original source... Go to PubMed...
  3. Cibula D, Stárka L, Vrbíková J a kol. Syndrom polycystických ovarií. Praha: Jessenius - Maxdorf 2004: 110.
  4. Fait T. Klimakterická medicina. Praha: Jessenius-Maxdorf 2006: 103.
  5. Falsetti L, Gambera A, Legrenzi L, Iacobello C, Bugari G. Comparison of finasterid versus flutamide in the treatment of hirsutism. Europ. J. Endocr. 1999; 141: 361-367. Go to original source... Go to PubMed...
  6. Frank-Raue K, Junga G, Vescei P, Ziegler R. Therapy of hirsutism in females with adrenal enzyme defects of streoid hormone biosynthesis: comparison of dexamethasone with cyproterone acetate. Klin. Wochenschr. 1990; 68(12): 597-601. Go to original source... Go to PubMed...
  7. Hampel H, Kotter HU, Padberg F et al. Sever hirsutizmus with psychoframacological tretment in major depression. World J. Biol. Psychiatry 2001; 2(1): 48-49. Go to original source... Go to PubMed...
  8. Kršek M, Hána V et al. Cushingův syndrom. Praha: Galén, 2006: 144.
  9. Morrell MJ, Isojarvi J, Taylor AE et al. Higher androgens and weight gain with Valproate compared with lamotrigine for epilepsy. Epilepsy Res. 2003; 54(2-3): 189-199. Go to original source... Go to PubMed...
  10. Rosenfield RL. Hirsutism and variable response of the pilosebaceous units on androgen. J. Invest. Dermatol. Symp. Proc. 2005; 10(3): 205-208. Go to original source... Go to PubMed...
  11. Schindler E. Antiandrogenic progestins for signs of androgenisation and hormonal contraception. Clin. Endocr. 2000; 52: 587-594.
  12. Spritzer PM, Lisboa S, Mattiello S, Lhullier F. Spironolactone as a single agent for long-term therapy of hirsute patients. Eur. J. Obst. Gynecol. Repr. Biol. 2004; 112(2): 136-141.
  13. Thorin-Savoure A., Kuhn JM. Hyperandrogenism and pregnancy. Ann. Endocr. 2002; 63(5): 443-451.
  14. Tosi A, Miscali C, Piraccini BM et al. Drug-induced hair loss and hair growth. Incidence, menagement and avoidance. Drug Saf. 1994; 10(4): 310-317. Go to original source... Go to PubMed...
  15. Van der Spuy ZM, Le Roux PA. Cyproterone acetate for hirsutism. Cochrane database Syst. Rev. 2003;(4): CD001125. Go to original source...
  16. Wendelin DS, Pope DN, Mallory SB. Hypertrichosis. J. Amer. Acad. Dermatol. 2003; 48(2): 161-179. Go to original source... Go to PubMed...
  17. Zwimpfer J. Hirsutism. Polycystic ovaries with suspected metabolic syndrome. Schweitz Rundsch. Med. Prax. 1999; 86(14): 1093-1095.




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