Med. praxi. 2010;7(4):177-182

Systemic lupus erythematosus - a prototype of the autoimmune disorder, diagnosis, therapy

doc.MUDr.Pavel Horák, CSc., MUDr.Martina Skácelová, MUDr.Andrea Smržová, doc.MUDr.Josef Zadražil, CSc., MUDr.Hana Ciferská, MUDr.Tomáš Tichý, MUDr.Zuzana Heřmanová, Mgr.Kateřina Langová, MUDr.Martin Žurek

III. interní klinika, FN a LF UP Olomouc

Oddělení klinické imunologie, FN a LF UP Olomouc

Autoimmunity is a process, in which some parts of the immune systém recognize the own organizm and cause its damage. Systemic

lupus erythematosus is a prototype of the autoimmune organ non-specific disorder. It affects predominantly young females. Lupus is

highly heteregenous disease with various clinical manifestations and prognosis. The correct identification of the autoimmune clinical

symptoms, testing for auto-antibodies, assessment of disease activity and organ damage play the crucial role in the SLE diagnosis.

The therapy of the severe forms of SLE should be coordinated by a specialist. The axis of the SLE therapy comprises glucocorticoids,

antimalarials, immunosupressive and, in the case of antiphospholipid syndrome, antikoagulant drugs. In recent year new drugs for

severe or moderate lupus are emerging and tested in clinical trials.

Keywords: autoimmunity, systemic lupus erythematosus (SLE), diagnosis, auto-antibodies, therapy

Published: May 1, 2010  Show citation